Heart Transplant Test

Heart Transplant Test

A heart transplant is an operation in which a failing, diseased heart is replaced with a healthier, donor heart. Heart transplant is a treatment that's usually reserved for people who have tried medications or other surgeries, but their conditions haven't improved sufficiently.
While a heart transplant is a major operation, your chance of survival is good, with appropriate follow-up care.
When faced with a decision about having a heart transplant, know what to expect of the heart transplant process, the surgery itself, potential risks and follow-up care.

Why it's done
Heart transplants are performed when other treatments for heart problems haven't worked, leading to heart failure. In adults, heart failure can be caused by:

-Coronary artery disease
-A weakening of the heart muscle (cardiomyopathy)
-Valvular heart disease
-A heart problem you're born with (congenital heart defect)
-Failure of a previous heart transplant
-In children, heart failure is most often caused by either a congenital heart defect or a cardiomyopathy.

A heart transplant isn't the right treatment for everyone, however. Certain factors may mean you're not a good candidate for a heart transplant. While each case is considered individually by a transplant center, a heart transplant may not be appropriate if you:

-Are age 65 or older
-Have another medical condition that could shorten your life, regardless of receiving a donor heart
-Have serious blockages in the arteries in your arms or legs (peripheral artery disease)
-Have a personal medical history of cancer
-Are unwilling or unable to make lifestyle changes necessary to keep your donor heart healthy, such as not drinking alcohol or not smoking

For some people who can't have a heart transplant, another option may be a ventricular assist device (VAD). A ventricular assist device is a miniature pump implanted in your chest that helps pump blood through your body. VADs are commonly used as a temporary treatment for people waiting for a heart transplant, but are increasingly being used as a permanent treatment for heart failure.

Risks

Although receiving a donor heart can save your life, having a heart transplant has many risks. The most significant risk is your body rejecting the donor heart.

Rejection of the donor heart
Your immune system will see your donor heart as a foreign object that's not supposed to be in your body. Your immune system will try to attack your donor heart. Although all people who receive a heart transplant receive immunosuppressants - medications that reduce the activity of the immune system - nearly 25 percent of heart transplant recipients still have some signs of rejection during the first year after transplantation.

Usually the rejection is without any symptoms and requires only an adjustment of medications. If you miss doses of medications, however, the rejection can be severe and very serious. It's important that transplant recipients follow the instructions outlined by their doctors.

To determine whether your body is rejecting the new heart, you'll have frequent biopsies of the new heart for several months after your transplant. During the biopsy, a tube is inserted into a vein in your neck or groin and directed to your heart. A biopsy device is run through the tube to extract a tiny sample of heart tissue, which is examined in a lab.

Because rejection is most likely to occur in the first few months after heart transplantation, the frequency of heart biopsies is greatest during this early period. It's possible you'd have signs or symptoms that your body is rejecting your donor heart. These signs and symptoms could include:

-Shortness of breath
-Fever
-Weight gain due to water retention
-Not urinating as much as usual
-Fatigue

Additional risks
Other risks after your heart transplant include:

-Problems with your arteries. After your transplant, it's possible the walls of the arteries in your heart could thicken and harden, leading to cardiac allograft vasculopathy (CAV). This can make blood circulation through your heart difficult and can cause a heart attack, heart failure, heart arrhythmias or sudden cardiac death.
-Medication side effects. The immunosuppressants you'll need to take for the rest of your life may cause serious kidney damage and other problems.
-Cancer. Immunosuppressants can also increase your cancer risk. Taking these medications can put you at a greater risk of skin and lip tumors and non-Hodgkin's lymphoma, among others.
-Infection. Immunosuppressants decrease your ability to fight infection. Many people who have heart transplants have an infection that requires them to be admitted to the hospital the first year after their transplant.

How you prepare

Preparations for a heart transplant often begin long before the surgery to place a transplanted heart. You may begin preparing for a heart transplant weeks or months before you receive a donor heart.

Taking the first steps
If your doctor recommends that you consider a heart transplant, you will likely be referred to a heart transplant center for an evaluation. You're also free to select a transplant center on your own. Check with your health insurance provider to see which transplant centers are covered under your insurance plan.

When evaluating a heart transplant center, consider the number of heart transplants a center performs each year and transplant recipient survival rates. You can compare transplant center statistics on the Web using a database maintained by the Scientific Registry of Transplant Recipients.

Also consider additional services provided by a transplant center. Many centers coordinate support groups, assist with travel arrangements, help you find local housing for your recovery period or direct you to organizations that can help with these concerns.

Once you decide where you would like to have your heart transplant, you'll need to have an evaluation to see if you're eligible for a transplant. The evaluation will check to see if you:

-Have a heart condition that would benefit from transplantation
-Might benefit from other less aggressive treatment options
-Are healthy enough to undergo surgery and post-transplant treatments
-Will agree to quit smoking, if you smoke
-Are willing and able to follow the medical program outlined by the transplant team
-Can emotionally handle the wait for a donor heart
-Have a supportive network of family and friends to help you during this stressful time

Waiting for a donor organ
If the transplant center medical team determines that you're a good candidate for a heart transplant, the center will register you on a waiting list. At any given time, there are about 3,000 people in the U.S. waiting for heart transplants. Unfortunately, there aren't enough hearts for every person in need, and some people die while waiting for a transplant.

While you're on the waiting list, your medical team will monitor your heart and other organs and alter your treatment as necessary. Your transplant team may temporarily remove your name from the waiting list if you develop a significant medical condition, such as a severe infection or stroke, which makes you temporarily unable to have a transplant while you recover.

If medical therapy fails to support your vital organs as you wait for a donor heart, your doctors may recommend you have a device implanted to support your heart while you wait for a donor organ. These devices are known as ventricular assist devices (VADs). The devices are also referred to as a bridge to transplantation because they gain you some time until a donor heart is available.

When a donor heart becomes available, the donor-recipient matching system considers these factors to make a match:

-Medical urgency of potential recipients
-Blood type (A, B, AB or O)
-Antibodies the recipients may have developed
-Size of the donor organ
-Time spent on the waiting list

Immediately before your transplant surgery
A heart transplant usually needs to occur within four hours of organ removal for the donor organ to remain usable. As a result, hearts are offered first to a transplant center close by, then to centers within certain distances of the donor hospital. The transplant center will provide you with a pager or cellphone to notify you when a potential donor organ is available. You must keep your cellphone or pager charged and turned on at all times.

When you're notified, you and your transplant team have a limited amount of time to consider whether to accept the donation, and you'll be expected to travel to the transplant hospital immediately after being notified of the potential donation.

As much as possible, you should make travel plans ahead of time. Some heart transplant centers provide private air transportation or other travel arrangements. Have a suitcase packed with everything you'll need for your hospital stay, as well as an extra 24-hour supply of your medications.

Result

Most people who receive a heart transplant enjoy a high quality of life. They can return to work within three to six months of a heart transplant and have few activity restrictions.

Recipient survival rates vary based on a number of factors. For example, in the U.S. the overall survival rate is about 88 percent after one year and about 75 percent after five years.

What if your new heart fails?
Heart transplants aren't successful for everyone. Your new heart may fail because of organ rejection or because of the development of valvular heart disease or coronary artery disease. Should this happen, your doctor may recommend adjusting your medications or in more extreme cases, another heart transplant.

In some cases, additional treatment options are limited and you may choose to stop treatment. Discussions with your heart transplant team, doctor and family should address your expectations and preferences for treatment, emergency care and end-of-life care.